TocilizumabV1, France, Analysis, bibRecord, 000044

Childhood-onset Takayasu Arteritis

Identifieur interne : 000044 ( France/Analysis ); précédent : 000043; suivant : 000045

Childhood-onset Takayasu Arteritis

Auteurs : Florence A. Aeschlimann [France, Suisse] ; Marinka Twilt [Canada] ; Rae S. M. Yeung [Canada]

Source :

European Journal of Rheumatology [ 2147-9720 ] ; 2020.

RBID : PMC:7004266

Abstract

Childhood-onset Takayasu Arteritis (cTAK) is a rare, large-vessel type of vasculitis seen in children, mainly affecting the aorta and its major branches. Clinical manifestations are often severe and arise as a result of systemic and local inflammation, along with end-organ ischemia. Disease flares are common and the disease burden is high, with a significant rate of morbidity and mortality. Recent advances in understanding the underlying disease pathobiology resulted in the use of pathway-targeting agents, such as TNF- or IL-6 inhibitors with improved disease control. Nonetheless, the prognosis often remains guarded and the accrued damage is significant. This review aims at summarizing the recent evidence and observations regarding this condition, with a focus on pediatric publications.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004266

DOI: 10.5152/eurjrheum.2019.19195
PubMed: NONE
PubMed Central: 7004266

Affiliations:

Canada, France, Suisse
Alberta, Ontario, Île-de-France
Calgary, Paris, Toronto
Université de Calgary, Université de Toronto

Links to Exploration step

PMC:7004266

Le document en format XML

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<author><name sortKey="Aeschlimann, Florence A" sort="Aeschlimann, Florence A" uniqKey="Aeschlimann F" first="Florence A." last="Aeschlimann">Florence A. Aeschlimann</name>
<affiliation wicri:level="3"><nlm:aff id="af1-ejr-7-suppl1-s58">Paediatric Immunology, Hematology and Rheumatology Unit, Hopital Necker - Enfants Malades, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
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<front><div type="abstract" xml:lang="en"><p>Childhood-onset Takayasu Arteritis (cTAK) is a rare, large-vessel type of vasculitis seen in children, mainly affecting the aorta and its major branches. Clinical manifestations are often severe and arise as a result of systemic and local inflammation, along with end-organ ischemia. Disease flares are common and the disease burden is high, with a significant rate of morbidity and mortality. Recent advances in understanding the underlying disease pathobiology resulted in the use of pathway-targeting agents, such as TNF- or IL-6 inhibitors with improved disease control. Nonetheless, the prognosis often remains guarded and the accrued damage is significant. This review aims at summarizing the recent evidence and observations regarding this condition, with a focus on pediatric publications.</p>
</div>
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   |étape=   Analysis
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   |texte=   Childhood-onset Takayasu Arteritis
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Childhood-onset Takayasu Arteritis

Childhood-onset Takayasu Arteritis

Source :

Abstract

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Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki

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